Probiotics HU58 Bacillus subtilis
Bacillus subtilis (HU58®)

Spore probiotics are being used extensively in humans as dietary supplements, in animals as growth promoters and competitive exclusion agents and lastly in aquaculture for enhancing the growth and disease resistance.

Bacillus subtilis (HU58®) is more stable in the in the acidic stomach environment, can grow and sporulate in anaerobic G I tract, having high sporulation efficiency, form biofilms which enhance gut colonization, produce surfactant which enhances the gut adhesion. The ability of B. subtilis cells and spores to interact with the intestinal epithelial cells and stimulate the GALT (Gut Associated Lymphoid Tissue), together with the absence of any sign of toxicity both in vitro and in vivo, suggests that ingestion of B. subtilis could have beneficial effects in strengthening the immune system and perhaps priming it for an adaptive immune response.

What makes HU58® Unique
  • Human origin.
  • Stable at room temperature (up to 45ºC) and also up to 80ºC. No need of refrigeration.
  • Proven stability in high temperature baking application such as biscuits at 235ºC for 8 minutes.
  • Have longer and better shelf life with high sporulation efficiency.
  • Extremely stable in the acidic conditions of the stomach thus reaches the intestine intact and ensures high bioavailability.
  • Produces biofilms with HU58® strain producing the most robust growth.
  • Biofilm enables adherence of B. subtilis to the mucosal epithelium, facilitate sporulation & protect the colony from gastric & bile juices.
Probiotics HU58®

The Benefits Of HU58®

  • Bacillus subtilis is one of the dominant components of the normal gut microflora.
  • B. subtilis spores are highly resistant to temperature, extreme pH, gastric acid; bile and solvents, hence keep viability in the gut. B. subtilis can be stored for long time periods without refrigeration.
  • B. subtilis is the most productive species which devotes 4–5% of its genome to antibiotic synthesis and produce 66 antibiotics. These substances have antimicrobial effects against broad spectrum of pathogens.
  • In the gut, B. subtilis spores not only germinate but also resporulate from vegetative cells. Sporulation of B. subtilis plays a major role in the development of GALT – Gut Associated Lymphoid Tissue which is important for both adaptive and innate immunity.
  • B. subtilis enhances the protection against pathogens by stimulating nonspecific and specific immunity.
  • Bacillus subtilis restores balance in gut microflora: beneficial species of Bifidobacterium, Lactobacillus, Butyricicoccus spp. increases while gut-damaging species of Acinetobacter, Ruminococcus, Clostridium and Veillonella decreases.
  • Bacillus subtilis helps retain gut barrier integrity, decreases endotoxin concentration and reduces gut inflammation.
  • Bacillus subtilis HU58® increases levels of Short Chain Fatty Acids (SCFA) mainly butyrate, which has beneficial effects on the development of a healthy immune system, is an important energy source for colonic epithelium, plays an important role in maintenance of gut barrier function through stimulation of tight junction integrity and mucin production.
  • Bacillus subtilis secretes many digestive enzymes such as protease, amylase, lipases and cellulase that aid in digestion of food. It also produces B-group vitamins and Vitamin K2 in the gut.
  • B. subtilis is one of the most important probiotics for the treatment and prophylaxis of intestinal disorders in humans such as acute/chronic diarrhea and antibiotic associated diarrhea (AAD). It has also been used to improve symptoms of IBS & IBD.


HU58® is a Bacillus subtilis strain isolated from the gastro-intestinal tract of healthy humans.

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